The study by Qilin Zhang and colleagues published in The Lancet Diabetes & Endocrinology evaluates the risk of recurrence following successful surgery for Cushing's disease and examines its association with USP8 genotype and tumour size.1 With 435 patients included, it represents one of the largest investigations to date exploring genotype–phenotype associations in Cushing's disease. The findings suggest a robust and clinically relevant predictor of long-term outcomes, which is particularly important given that disease recurrence following initially successful transsphenoidal surgery remains a substantial clinical challenge.
The Lancet Diabetes & Endocrinology published a clinical update in Research Highlights on 02 Mar 2026.
The item focuses on USP8 genotype and tumour size as predictors for recurrence in Cushing's disease.
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