Overcoming Immune Imprinting With the COVID-19 LP.8.1 MRNA Boosters

09 Feb 20264 min read0 viewsJournal Feed

GIST

In summer 2025, the SARS-CoV-2 JN.1 sublineage became dominant with more resistant variants, such as XFG, LP.8.1, and NB.1.8.1. COVID-19 mRNA boosters were therefore updated for the 2025–2026 season to target the LP.8.1 spike.1 Previous boosters, particularly the WA1/2020+BA.5 bivalent booster, were characterised by substantial boosting of the ancestral strain, a phenomenon known as immune imprinting.2,3 We therefore evaluated whether the phylogenetically more distant LP.8.1 mRNA booster would preferentially boost currently circulating strains.

Clinical Editorial

Summary

The Lancet Infectious Diseases published a clinical update in Infectious Disease on 09 Feb 2026.

The item focuses on Overcoming immune imprinting with the COVID-19 LP.8.1 mRNA boosters.

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Source Reference

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DOI

10.1016/S1473-3099(26)00050-2

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Source

The Lancet Infectious Diseases