PNASPublic Health
Hyperactive Rac converts sublethal to lethal trogocytosis in vivo
Summary
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceRac is a key protein in the cellular eating process called phagocytosis. Rac hyperactivity enhances the consumption of tumor cells by chimeric antigen receptor-macrophages (CAR-M), a promising type of cellular immunotherapy. Elucidating the ...
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceRac is a key protein in the cellular eating process called phagocytosis. Rac hyperactivity enhances the consumption of tumor cells by chimeric antigen receptor-macrophages (CAR-M), a promising type of cellular immunotherapy. Elucidating the ...