PNASPublic Health
Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases
Summary
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceOur study uncovered a signaling network that connects four universal and powerful cellular signaling systems—intracellular Ca2+, membrane potential, phosphatidylinositol 4,5-bisphosphate (PIP2), and temperature—linked together by TRPM4, a ...
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceOur study uncovered a signaling network that connects four universal and powerful cellular signaling systems—intracellular Ca2+, membrane potential, phosphatidylinositol 4,5-bisphosphate (PIP2), and temperature—linked together by TRPM4, a ...