PNASPublic Health
Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis
Summary
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceBacterial sepsis remains a major global health burden. Here, we report an essential role for the recently discovered acid-sensitive chloride channel, Proton-activated chloride channel 1 (PACC1) (PAC/ASOR/TMEM206), in protective host defense ...
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceBacterial sepsis remains a major global health burden. Here, we report an essential role for the recently discovered acid-sensitive chloride channel, Proton-activated chloride channel 1 (PACC1) (PAC/ASOR/TMEM206), in protective host defense ...