PNASPublic Health
AI-derived therapeutic development of a serotonin receptor–targeting drug for the treatment of opioid use disorder
Summary
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceThe premise of these studies was to develop and validate a therapeutic for opioid use disorder. Using an AI-based platform aimed at polypharmacy-focused drug discovery, two compounds were synthesized and tested, GATC-021 and GATC-1021. We ...
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceThe premise of these studies was to develop and validate a therapeutic for opioid use disorder. Using an AI-based platform aimed at polypharmacy-focused drug discovery, two compounds were synthesized and tested, GATC-021 and GATC-1021. We ...