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Structure basis for C-C chemokine receptor 4 modulation by orthosteric and allosteric antagonists
Summary
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceC-C chemokine receptor 4 (CCR4) guides immune cells to sites of inflammation and tumors and plays a central role in certain leukemias and lymphomas. It has emerged as a promising target for cancer immunotherapy and the treatment of immune ...
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceC-C chemokine receptor 4 (CCR4) guides immune cells to sites of inflammation and tumors and plays a central role in certain leukemias and lymphomas. It has emerged as a promising target for cancer immunotherapy and the treatment of immune ...