PNASPublic Health
Oocyte-inspired universal whole-cell vaccines against tumor heterogeneity
Summary
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceTumor heterogeneity undermines cancer-vaccine efficacy by presenting a complex and patient-specific antigenic landscape. Inspired by the zona pellucida, an extracellular armor that safeguards the oocyte, we engineered a biomimetic whole-tumor-...
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceTumor heterogeneity undermines cancer-vaccine efficacy by presenting a complex and patient-specific antigenic landscape. Inspired by the zona pellucida, an extracellular armor that safeguards the oocyte, we engineered a biomimetic whole-tumor-...