PNASPublic Health
Aging alters DNA structure–induced genetic instability in mice
Summary
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceGenetic instability is a hallmark of aging and disease. Z-DNA has been implicated in the etiology of age-related diseases such as Alzheimer’s and cancer. We have previously shown that Z-DNA can stimulate DNA double-strand breaks, resulting in ...
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceGenetic instability is a hallmark of aging and disease. Z-DNA has been implicated in the etiology of age-related diseases such as Alzheimer’s and cancer. We have previously shown that Z-DNA can stimulate DNA double-strand breaks, resulting in ...