PNASPublic Health
Targeted degradation of c-Myc through the midnolin–proteasome pathway
Summary
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceAlthough PROTACs have revolutionized drug discovery, they face limitations regarding E3 ligase reliance and resistance, while emerging lysosomal strategies are often unsuitable for intranuclear targets. Addressing the challenge of degrading ...
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceAlthough PROTACs have revolutionized drug discovery, they face limitations regarding E3 ligase reliance and resistance, while emerging lysosomal strategies are often unsuitable for intranuclear targets. Addressing the challenge of degrading ...