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A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation
Summary
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceThe Arg/N-degron pathway of the yeastSaccharomyces cerevisiaetargets proteins for degradation via its targeting complex that contains the Ubr1/Ufd4 E3 ubiquitin ligases. Ubr1 E3 recognizes destabilizing N-terminal residues (N-degrons) of ...
Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. SignificanceThe Arg/N-degron pathway of the yeastSaccharomyces cerevisiaetargets proteins for degradation via its targeting complex that contains the Ubr1/Ufd4 E3 ubiquitin ligases. Ubr1 E3 recognizes destabilizing N-terminal residues (N-degrons) of ...