High-Intensity Interval Training Remodels Adipose Tissue Inflammatory Signaling and Enhances Immunometabolic Health via microRNA Regulation

07 Jul 20264 min read0 viewsVerified Feed

GIST (Key Takeaways)

Sedentary behavior promotes chronic low-grade inflammation in adipose tissue, contributing to metabolic dysfunction and insulin resistance. High-intensity interval training (HIIT) is a time-efficient exercise strategy with potent anti-inflammatory and metabolic benefits; however, its effects on adipose tissue inflammatory signaling and microRNA (miRNA) regulation remain incompletely understood.
This study investigated the effects of eight weeks of HIIT on inflammatory and epigenetic markers in interscapular white adipose tissue (iWAT) of male Wistar rats. Fourteen rats were randomly assigned to either a sedentary (SED; n = 7) or HIIT (n = 7) group.
The HIIT protocol consisted of treadmill running five days per week for eight weeks. Body weight and iWAT mass were assessed, and molecular adaptations were evaluated at multiple regulatory levels using RT-qPCR for mRNA targets (NLRP3, TNF-, PPAR-{gamma}, and IL-10) and miRNAs (miR-21 and miR-30d-5p), while protein levels of NLRP3 and PPAR-{gamma} were assessed using Western blotting.
Compared with the SED group, HIIT significantly reduced body weight (p < 0.001) and iWAT mass (p = 0.002).

Clinical Editorial

bioRxiv (Biomedical Preprints) published a clinical update in Research Highlights on 07 Jul 2026.

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