Multi-omics maps human–pig interactions in extracorporeal liver cross-circulation

15 Jul 20264 min read0 viewsJournal Feed

GIST (Key Takeaways)

Spatial and circulating multi-omics of pig-to-human extracorporeal liver cross-circulation reveals an early innate immune response, species-specific complement dynamics and xenograft–platelet interactions, while showing preserved metabolic support even after removal of the native liver. Von Willebrand factor, endothelium, hepatocytes, and resident and infiltrating immune cells were implicated in xenograft-associated thrombocytopenia. Shaked, A. et al. Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents. Nat. Med.
32 , 1034–1044 (2026). This paper reports the clinical procedures and primary findings from the five ELC experiments included in the present study. Schmauch, E. et al. Multi-omics analysis of a pig-to-human decedent kidney xenotransplant. Nature 650 , 205–217 (2026). This paper reports the multi-omics analysis of a pig-to-human kidney xenotransplantation procedure; the methodological framework used in the present study was partly inspired by this work.
Tao, K.-S. et al. Gene-modified pig-to-human liver xenotransplantation. Nature 641 , 1029–1036 (2025). This paper describes the first reported pig-to-human liver xenotransplantation performed in a human decedent recipient. Zhang, W. et al.
Genetically engineered pig-to-human liver xenotransplantation. J. Hepatol. 84 , 587–598 (2026).