Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU)

16 Apr 20265 min read0 viewsJournal Feed

GIST (Key Takeaways)

Introduction Patients discharged from intensive care units (ICUs) are at high risk of adverse long-term outcomes including cardiovascular and/or renal events and a 1-year mortality of approximately 22%. Plasma biomarkers measured at ICU discharge have demonstrated strong prognostic value, with elevated cardiac or renal biomarkers identifying patients at particularly high risk of poor outcomes. Sodium-glucose cotransporter 2 inhibitors are now widely recognised for their cardioprotective and nephroprotective effects in chronic conditions such as type 2 diabetes, heart failure or chronic kidney disease. These agents improve both morbidity and mortality across a range of high-risk populations. We hypothesise that a therapeutic strategy aimed at preventing the progression of cardiovascular and/or renal injury following ICU discharge may improve long-term outcomes in ICU survivors.
Method and analysis This is a multicentre, double-blind, randomised, placebo-controlled clinical trial conducted across 16 teaching and non-teaching ICUs in France. We will enrol 600 adult patients (18 years of age or older) who have received mechanical ventilation and/or vasopressors for at least 24 hours during their ICU stay, and who meet at least one of the following criteria at ICU discharge: N-terminal pro-B-type natriuretic peptide (NT-proBNP) >800 pg/mL or BNP >90 ng/L, an estimated glomerular filtration rate between 25 and 90 mL/min/m². Eligible patients will be randomised in a 1:1 ratio to receive either dapagliflozin (10 mg once daily) or a matching placebo for a duration of 1 year. The primary outcome is a composite endpoint assessed at 1 year after randomisation, comprising: all-cause mortality, unscheduled hospitalisation for acute heart failure and decrease in renal function. Feasibility will be assessed based on patient and clinical acceptability and recruitment performance, including enrolment rates across participating centres.
Ethics and dissemination This study has been approved by the Institutional Review Board (CPP Ile-de-France 5). Written informed consent will be obtained from all participants prior to enrolment and the initiation of any study-related procedures. Dapagliflozin is a widely available medication with an established safety profile. If proven effective, it would represent a readily deployable strategy to improve long-term outcomes in ICU survivors. The study is described in accordance with the Standard Protocol Items: Recommendations for Interventional Trials framework, and key design features and methodological decisions are outlined accordingly.
DAPA-ICU aims to evaluate the efficacy of dapagliflozin in cardiorenal protection among critically ill patients following ICU discharge. The main trial results will be submitted for publication in a peer-reviewed journal as soon as they become available after final analysis. Trial registration number NCT07025629 .

Clinical Editorial

BMJ Open published a clinical update in Research Highlights on 16 Apr 2026. The item focuses on Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU). Open the detail page to review the full original feed content.

Source Reference

Read the full original publication from the source journal or publisher link below.

Open Original Source More Feed Items

Related by Condition/Drug

Endocrine NewsRelated by Conditiondapagliflozindiabetes

Beyond the Scale: What Else Glucagon-like Peptide-1 Receptor Agonists Can Do

Research Highlights • 13 Feb 2026

Cardiovascular and renal outcomes of combined SGLT2 inhibitors and GLP-1 receptor agonists versus monotherapy in patients with type 2 diabetes mellitus: a network meta-analysis [Research]

Research Highlights • 13 Jul 2026

Med News TodayRelated by Conditiondiabetesheart failure

Synthetic Data-Augmented Machine Learning for 30-Day Readmission Prediction in Chronic Condition

Research Highlights • 03 Apr 2026

Feed Metadata

Source

BMJ Open

Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU)

GIST (Key Takeaways)

Clinical Editorial

Source Reference

Related by Condition/Drug

Beyond the Scale: What Else Glucagon-like Peptide-1 Receptor Agonists Can Do

Cardiovascular and renal outcomes of combined SGLT2 inhibitors and GLP-1 receptor agonists versus monotherapy in patients with type 2 diabetes mellitus: a network meta-analysis [Research]

Minor Cardiac Dysfunction Linked To Later Brain Changes In Study

MRI-Derived Abdominal Subcutaneous Fat And Heart Failure Risk

Lifestyle Changes May Help Prevent Multimorbidity In Prediabetes

Synthetic Data-Augmented Machine Learning for 30-Day Readmission Prediction in Chronic Condition

Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU)

GIST (Key Takeaways)

Clinical Editorial

Source Reference

Related by Condition/Drug

Beyond the Scale: What Else Glucagon-like Peptide-1 Receptor Agonists Can Do

Cardiovascular and renal outcomes of combined SGLT2 inhibitors and GLP-1 receptor agonists versus monotherapy in patients with type 2 diabetes mellitus: a network meta-analysis [Research]

Minor Cardiac Dysfunction Linked To Later Brain Changes In Study

MRI-Derived Abdominal Subcutaneous Fat And Heart Failure Risk

Lifestyle Changes May Help Prevent Multimorbidity In Prediabetes

Synthetic Data-Augmented Machine Learning for 30-Day Readmission Prediction in Chronic Condition