Objectives This study aimed to investigate the relationship between left ventricular (LV) remodelling and systolic function in high-gradient severe aortic stenosis (AS) using cardiovascular magnetic resonance (CMR) imaging. Patients with low ejection fraction (left ventricular ejection fraction (LVEF) Design This was a cross-sectional study design.
Setting The study was performed at a single tertiary academic hospital in the Western Cape, South Africa. Participants A total of 48 participants with high-gradient (mean gradient ≥40 mm Hg) severe AS (aortic valve area (AVA) 2 ) were consecutively recruited.
Of 48 participants, 24 (50%) had LEF-HG AS (mean AVA 0.52±0.18 cm 2 , mean gradient 54 (21) mm Hg, mean LVEF 29±11%). The remainder of the cohort had NEF-HG AS (mean AVA 0.70±0.17 cm 2 , mean gradient 53 (25) mm Hg, LVEF 64±14%).
Results End-systolic wall stress (ESWS) was higher in the LEF-HG group (265.3±83.5 vs 122.8±54.7 x 10 3 dynes/cm 2 ; p 0.99) was identical between the groups.
BMJ Open published a clinical update in Research Highlights on 24 Jun 2026.
The item focuses on Morphological and functional evaluation of the left ventricle in severe aortic stenosis with afterload mismatch: a South African single-centre, cross-sectional cardiovascular MRI-based study.
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