Cancer-associated cachexia is a complex metabolic syndrome leading to sustained body weight loss and tissue wasting. In this issue of Cancer Cell, Shi et al. identify a novel GDF15-driven tumor-immune-brain crosstalk, resulting in altered systemic metabolism and tissue catabolism.
Cancer Cell published a clinical update in Oncology on 05 Mar 2026. The item focuses on A closed tumor-immune-brain circuit in cancer cachexia. Open the detail page to review the full original feed content.