Extract Preserved ratio impaired spirometry (PRISm) is defined by a reduced forced expiratory volume in 1 s (FEV 1 1 /forced vital capacity (FVC) ratio (≥0.70). Prevalence estimates vary (~5 - 20%) by definition and population. Although this pattern does not fulfil the criteria for spirometry-defined airflow obstruction, PRISm has been increasingly recognised as a distinct and clinically relevant spirometric phenotype, associated with respiratory symptoms, reduced functional capacity, and increased all-cause mortality [1, 2], sometimes even approaching the risk seen in mild-to-moderate COPD [3].
European Respiratory Journal published a clinical update in Critical Care on 12 Mar 2026.
The item focuses on Bronchodilator reversibility, body plethysmographic phenotypes, and mortality in patients with COPD or PRISm.
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