Bronchodilator Reversibility, PRISm Phenotypes, and Mortality in COPD and PRISm

12 Mar 20264 min read0 viewsJournal Feed

GIST (Key Takeaways)

Extract Preserved ratio impaired spirometry (PRISm) is defined by a reduced forced expiratory volume in 1 s (FEV 1 1 /forced vital capacity (FVC) ratio (≥0.70).
Prevalence estimates vary (~5 - 20%) by definition and population.
Although this pattern does not fulfil the criteria for spirometry-defined airflow obstruction, PRISm has been increasingly recognised as a distinct and clinically relevant spirometric phenotype, associated with respiratory symptoms, reduced functional capacity, and increased all-cause mortality [1, 2], sometimes even approaching the risk seen in mild-to-moderate COPD [3].