BackgroundCurrent therapeutic options for severe acute pancreatitis (SAP) remain limited. The integration of traditional Chinese and Western medicines offers a promising approach for patients with SAP, with Qingyi decoction (QYD) emerging as a classic and effective formula for this condition.
Nevertheless, its precise mechanism—particularly regarding ionomics and proteomics—requires further elucidation.PurposeThis study aimed to investigate the possible underlying mechanisms by exploring the characteristics and relationships of alterations in ionomics and proteomics profiles during pancreatic repair in a mouse model of SAP treated with QYD.MethodsThe therapeutic efficacy of QYD in SAP was validated through pathological section analysis and immunohistochemistry. Total elemental analysis of serum and mouse tissues was performed using inductively coupled plasma–mass spectrometry to identify relevant target elements.
XPS analysis was employed to determine the chemical speciation of the target elements. Proteomic analysis, combined with KEGG, GO enrichment and STRING protein–protein interaction analyses, elucidated the protein molecules and biological pathways and the core proteins involved in QYD-mediated SAP treatment were verified by Western blotting.
Frontiers in Immunology published a clinical update in Infectious Disease on 22 Apr 2026.
The item focuses on Ionomics and proteomics analysis of the pancreatic repair in a murine severe acute pancreatitis model treated with Qingyi decoction.
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