Integrative plasma proteomics and myeloid- interferon profiling reveal an AI-validated vascular- endothelial stress signature distinguishing SLE flare from remission in an Indian cohort a discovery – phase study

03 Jun 20266 min read0 viewsJournal Feed

GIST (Key Takeaways)

Background. Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by unpredictable flares and variable clinical quiescence. Despite validated clinical indices like the British Isles Lupus Assessment Group (BILAG) score, reliable molecular biomarkers for monitoring disease activity remain limited, particularly in underrepresented South Asian populations.
Weaimed to identify arobust molecular framework to distinguish SLE flares from remission in an Indian cohort. Methods. We conducted a discovery-phase study in an Indian cohort (n=16) stratified by Easy-BILAG scoring.
Plasma proteomic profiling via LC-MS/MS was integrated with targeted cytokine quantification using the Olink Proximity Extension Assay (PEA). Differential expression and network analyses delineated immune-regulatory, hypoxic-vascular, and myeloid-activation pathways. A Random Forest classifier was trained on selected biomarkers and evaluated using leave-one-out cross-validation (LOOCV), permutation testing, and bootstrapped AUROC confidence intervals, with model interpretability assessed by SHAP values.

Clinical Editorial

Summary

Frontiers in Immunology published a clinical update in Infectious Disease on 03 Jun 2026.

The item focuses on Integrative plasma proteomics and myeloid- interferon profiling reveal an AI-validated vascular- endothelial stress signature distinguishing SLE flare from remission in an Indian cohort a discovery – phase study.

Review the original article for the full source wording and details.