ObjectiveTo investigate the clinical and immunological features of primary Sjögren’s disease (pSjD) patients with anti-centromere protein B (CENP-B) antibody positivity and to evaluate its prognostic significance.MethodsThis ambispective cohort study included 1,222 patients with pSjD from the China–Japan Friendship Hospital between February 2014 and February 2023, with follow-up through February 2024. Patients were categorized into anti-CENP-B positive and negative groups based on serum testing.
Clinical characteristics, immunological features, and outcomes were compared between groups. A subgroup analysis compared patients with isolated CENP-B positivity to those with additional autoantibodies.
Statistical analyses were conducted using SPSS 26.0 and R 4.2.3, including descriptive statistics, univariate tests, and Kaplan-Meier survival analysis.ResultsIn this study, 100 patients (8.2%) were positive for anti-CENP-B antibody, while 1,122 patients (91.8%) were negative. Compared with the negative group, positive patients were older, more often female, and have higher rates of xerostomia and Raynaud’s phenomenon, but lower frequency of dyspnea.
Frontiers in Immunology published a clinical update in Infectious Disease on 23 Apr 2026.
The item focuses on Anti-centromere protein B antibody positivity in primary Sjögren’s disease: clinical features and prognostic implications.
Review the original article for the full source wording and details.