BackgroundGood’s syndrome (GS) is a rare acquired immunodeficiency defined by the co-occurrence of thymoma and hypogammaglobulinemia. Follicular helper T (Tfh) cells, a specialized CD4+ T cell subset, play a critical role in supporting B-cell antibody production.
The status and characteristics of Tfh cells in GS, however, remain largely unexplored.MethodsThis study utilized flow cytometry to analyze CD4+CXCR5+ T cells, along with Tfh1 (CXCR3+CCR6−), Tfh2 (CXCR3−CCR6−), and Tfh17 (CXCR3−CCR6+) subsets, in three GS patients compared to twenty healthy controls (HCs). Serum levels of Th1/Th2/Th17 cytokines were also assessed.ResultsThe cohort included a 45-year-old female and a 70-year-old female, both with type AB thymoma, and a 47-year-old male with type A thymoma.
All patients exhibited markedly reduced serum IgG levels (0.87 g/L, 1.44 g/L, 3.0 g/L) and a profound reduction or absence of peripheral B cells (0%, 0%, 3.7%). The proportions of CD4+CXCR5+ T cells and total Tfh cells in two patients (Cases 1 & 2) were comparable to HCs, while a significant increase was noted in the third patient (Case 3).
Frontiers in Immunology published a clinical update in Infectious Disease on 23 Apr 2026.
The item focuses on Significant decreased CXCR3+ phenotype Tfh1 cells in three Good’s syndrome patients.
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