Association between neutrophil percentage-to-albumin ratio and adverse clinical outcomes after successful percutaneous coronary intervention for chronic total occlusion: a cohort study

09 Jul 20264 min read0 viewsJournal Feed

GIST (Key Takeaways)

Background. Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has improved outcomes, yet residual cardiovascular risk persists. The neutrophil percentage-to-albumin ratio (NPAR), an integrated marker of inflammation and nutritional status, has not been examined in successfully revascularized CTO patients.
We investigated whether NPAR is independently associated with long−term adverse outcomes in this population. Methods. This single−center retrospective cohort study included 1513 consecutive patients who underwent successful CTO PCI.
NPAR was calculated as (neutrophil percentage × 100)/albumin (g/dL). The primary endpoint was all−cause mortality, secondary endpoints were cardiovascular mortality and cardiovascular events (cardiovascular death, non−fatal myocardial infarction, non−fatal stroke). Multivariable Cox regression and restricted cubic splines (RCS) assessed the association between NPAR and clinical outcomes.
Time-dependent Receiver operating characteristics (ROC) curves were used to evaluate the ability for NPAR to predict all-cause mortality. Results. During a median follow−up of 810 days, 83 (5.5%) all−cause deaths, 53 (3.5%) cardiovascular deaths, and 73 (4.8%) cardiovascular events occurred.

Clinical Editorial

Frontiers in Immunology published a clinical update in Infectious Disease on 09 Jul 2026.

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