Back to Clinical Feed
Try:
Front ImmunolInfectious Disease
MGST1 drives lymph node metastasis in papillary thyroid carcinoma via mitochondrial metabolic reprogramming and immune suppression
04 Jun 20264 min read0 viewsJournal Feed
GIST (Key Takeaways)
- Background. While papillary thyroid carcinoma (PTC) generally exhibits a favorable prognosis, a subset of patients experiences poorer outcomes, with lymph node metastasis (LNM) significantly increasing the risk of recurrence and correlating with a worse prognosis. Mitochondrial metabolic reprogramming and immune evasion play pivotal roles in driving lymph node metastasis; however, the specific actionable targets within these processes remain largely unexplored.
- Methods. We constructed a multi-omics discovery framework by integrating TCGA/GTEx transcriptomics, a large-scale independent clinical cohort, and single-cell RNA sequencing. Both mitochondrial metabolic signatures and immune evasion landscapes were investigated to characterize their roles in driving LNM.
- A consensus machine learning framework was deployed to isolate core drivers, which were rigorously validated through genetic manipulation and pharmacological assays. Results. Unsupervised clustering identified a high-risk “Mito-high” subtype, characterized by distinct metabolic reprogramming and an immunosuppressive microenvironment, in which CD8+ T cell depletion coincided with Treg enrichment.
- Machine learning prioritized MGST1 as the core predictor, consistently ranking as a top feature in both the integrated TCGA/GTEx dataset and our independent cohort. The MGST1-based model demonstrated robust predictive performance, achieving an AUC of 0.833 in external validation.
Clinical Editorial
Summary
Frontiers in Immunology published a clinical update in Infectious Disease on 04 Jun 2026.
The item focuses on MGST1 drives lymph node metastasis in papillary thyroid carcinoma via mitochondrial metabolic reprogramming and immune suppression.
Review the original article for the full source wording and details.
Source Reference
Read the full original publication from the source journal or publisher link below.
Related by Condition/Drug
Front ImmunolRelated by Specialty
Synergizing radiotherapy and immunotherapy for locally advanced gastric cancer: evolving paradigms and future directions
Infectious Disease • 26 Jun 2026
Front ImmunolRelated by Specialty
Adrenal tumor microenvironment: hormone–immune crosstalk, molecular heterogeneity, and immunotherapeutic opportunities
Infectious Disease • 26 Jun 2026
Nat ImmunolRelated by Specialty
Airway immune signatures of protection and disease progression in recent human tuberculosis household contacts
Infectious Disease • 24 Jun 2026
Nat ImmunolRelated by Specialty
Diversifying the antibody response to influenza virus with an mRNA-based vaccine
Infectious Disease • 23 Jun 2026
Feed Metadata
Source
Frontiers in Immunology
Category
Infectious Disease
Published
04 Jun 2026
Feed Metadata
Source
Frontiers in Immunology
Category
Infectious Disease
Published
04 Jun 2026