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Front ImmunolInfectious Disease

Grape seed proanthocyanidins supplementation attenuates diquat-induced intestinal barrier damage in weaned pigs

07 May 20264 min read0 viewsJournal Feed

GIST (Key Takeaways)

  • Objective. Grape seed proanthocyanidins (GSP) is a kind of plant polyphenols with a wide variety of biological activities. In the present study, we evaluated whether GSP can alleviate intestinal injury in weaned pigs injected with diquat.
  • Methods. A total of 32 pigs were randomly assigned to four groups (n = 8): (1) nonchallenged control; (2) control + 50 mg/kg GSP; (3) diquat-treated control and (4) diquat + 50 mg/kg GSP. On the morning of day 15, the pigs were injected with diquat (10 mg per kg body weight) or saline, and were then killed to obtain the serum and intestinal segments 7 days later.
  • Results. The results showed that GSP addition decreased (P < 0.05) the urea concentration and increased (P < 0.05) the total superoxide dismutase activity in serum of diquat-challenged pigs. GSP increased (P < 0.05) the ileal villus height and duodenal and ileal villus height to crypt depth ratio in diquat-challenged pigs.

Clinical Editorial

Summary

Frontiers in Immunology published a clinical update in Infectious Disease on 07 May 2026.

The item focuses on Grape seed proanthocyanidins supplementation attenuates diquat-induced intestinal barrier damage in weaned pigs.

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