ObjectiveTo investigate the correction value of inflammatory activity stratification on the diagnostic performance of liver stiffness measurement (LSM) for hepatic fibrosis in patients with autoimmune hepatitis (AIH), and to provide evidence for accurate fibrosis assessment in AIH patients.MethodsClinical data of AIH patients who underwent liver biopsy at our hospital from January 2017 to January 2026 were retrospectively analyzed. All patients underwent LSM by transient elastography within the same period.
Patients were divided into the G1–G2 group (mild-to-moderate inflammation) and G3–G4 group (severe inflammation) according to the simplified Scheuer inflammatory grade. Liver pathological fibrosis staging (S0–S4) served as the gold standard.
Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic performance of LSM. A correction model was constructed by multivariate logistic regression and internally validated using the Bootstrap method with 1000 resamplings.ResultsA total of 86 AIH patients were finally enrolled, including 79 females (91.9%) with a mean age of (54.1 ± 9.1) years.
There were 52 patients in the G1–G2 group and 34 in the G3–G4 group.
Frontiers in Immunology published a clinical update in Infectious Disease on 10 Jun 2026.
The item focuses on Inflammatory activity stratification improves liver stiffness diagnosis of fibrosis in autoimmune hepatitis.
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