Shigellosis is an intestinal infection causing severe and often life-threatening diarrheal disease, with high prevalence in children under five years of age in low- and middle-income countries. Given the rise of antimicrobial resistance to Shigella, the World Health Organization has included this pathogen among those for which the development of new interventions is a global health priority.
No vaccines against Shigella are licensed yet, but several candidates based on the O-antigen portion of lipopolysaccharides are in clinical development, and combining a Shigella vaccine with another vaccine has recently been recommended to broaden protection while minimizing the need for additional injections in an already crowded childhood immunization schedule. Here, in animal models, we present a novel combination vaccine strategy: a tetravalent GMMA−based Shigella vaccine co-formulated with a bivalent Salmonella glycoconjugate vaccine targeting S.
Typhi and S. Paratyphi A, the causative agents of typhoid and paratyphoid fever.
We demonstrate the technical feasibility of combining all six antigens without major impact on the humoral immune response to any component. Moreover, we show that Shigella GMMA can serve as a carrier for the S.
Frontiers in Immunology published a clinical update in Infectious Disease on 22 Apr 2026.
The item focuses on Preclinical evaluation of multivalent vaccine combinations against Shigella and Salmonella infections.
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