BackgroundThe predominant cause of lower back pain (LBP) is intervertebral disc degeneration (IVDD), which has a substantial financial cost to both individuals and society. In the pathophysiology of IVDD, the immune-inflammatory response is crucial.
The number of macrophages in the nucleus pulposus (NP) was positively correlated with the degree of IVDD. The extracellular matrix (ECM) disintegration, pyroptosis, and apoptosis of nucleus pulposus cells (NPCs) have all been demonstrated to have a significant impact on IVDD and are closely linked to immune-inflammatory regulation.
Meanwhile, we have shown that Duhuo Jisheng Decoction (DHJSD), which modulates the aforementioned pathways, can significantly alleviate IVDD. It’s unclear, nevertheless, if DHJSD can lessen IVDD by regulating macrophage modulation of the immune-inflammatory response.MethodsIn this study, we analyzed the relationship between different subtypes of macrophages and IVDD by using single-cell sequencing.
Afterwards, bioinformatics techniques were employed to investigate the primary target genes in IVDD.
Frontiers in Immunology published a clinical update in Infectious Disease on 21 Apr 2026.
The item focuses on Duhuo Jisheng Decoction ameliorates experimental intervertebral disc degeneration by modulating immune-inflammatory responses through regulation of macrophage polarization.
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