BackgroundT and B cells are central to adaptive immunity, where they identify and neutralize foreign antigens and cancer neo−antigens. Large−scale elucidation of T− and B−cell receptors (TCRs and BCRs) through immune−repertoire sequencing promises novel diagnostics, prognostic markers, and therapeutic strategies.
However, progress is hampered by small cohort sizes, a lack of real−world patient diversity, and heterogeneous sample processing, impeding cross−study comparability. To overcome these limitations, here we introduce the Human Blood Immunome Encyclopedia (HuBIE), comprising immune−repertoire data from 2,614 samples collected from 1,941 participants.
The cohort includes a range of bloodstream infections, several cancer types, and control participants, with many individuals providing longitudinal samples.MethodsWe employed Roche’s immune receptor Primer Extension Target Enrichment (immunoPETE) platform to perform simultaneous targeted sequencing of T and B cells heavy chains including T−cell receptor β chains (TRB), T−cell receptor δ chains (TRD), and immunoglobulin heavy chains (IGH), thereby profiling TCRs and BCRs in all participants.
Frontiers in Immunology published a clinical update in Infectious Disease on 18 Jun 2026.
The item focuses on HuBIE: The human blood immunome encyclopedia of TCRs and BCRs in bloodstream infections and cancer.
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