BackgroundAcute myeloid leukemia (AML) is a hematologic malignancy characterized by heterogeneity, poor prognosis, and limited biomarkers for risk prediction. Mitochondria pathway related genes (MPRGs), as central regulators of cellular metabolism and immune microenvironment dynamics, may provide useful information for prognostic assessment and biological characterization in AML.MethodsMPRGs were obtained from the MitoCarta3.0 database.
Univariate Cox and Kaplan-Meier methods were conducted to analyze their prognostic relevance. LASSO penalized regression followed by stepwise multivariate Cox analysis yielded an optimal gene panel in the TCGA-LAML dataset.
External validation was performed across three GEO datasets (GSE10358, GSE106291, GSE71014). Finally, the role of UCP2 was examined in vitro by assessing UCP2 knockdown effects on MOLM-13 cell behavior.ResultsA prognostic signature comprising seven MPRGs (UCP2, FAM162A, ACCS, HSD1, ACSF2, PPIF, and SDHA) was established.
High-risk patients exhibited significantly shorter survival. The MPRGs risk score served as an independent predictor of prognosis.
Moreover, elevated risk scores correlated with heightened immune checkpoint molecule expression and an immunosuppressive tumor microenvironment.
Frontiers in Immunology published a clinical update in Infectious Disease on 19 May 2026.
The item focuses on Identification and experimental validation of mitochondria pathway related genes in acute myeloid leukemia.
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