BackgroundPolymeric immunoglobulin receptor (PIGR) is a transmembrane protein widely expressed in mucosal epithelial cells that is involved in the transcytosis of the polymeric immunoglobulins IgA and IgM. Recent findings revealed increased plasma PIGR levels in subjects with subclinical atherosclerosis, although its function remains uncertain.PurposeTo assess the role of PIGR in atherosclerosis.MethodsWe analyzed PIGR levels in human atherosclerotic plaques compared to healthy aortic samples, as well as in the serum of subjects with peripheral arterial disease (PAD) and controls.
Next, we studied the effect of germline Pigr deficiency in experimental atherosclerosis (Ldlr−/−/Pigr−/− mice fed a western-diet for 10 weeks). Circulating IgA and IgM levels, as well as B and T cell numbers in spleen and Peyer’s patches (PP), were analyzed by ELISA and flow cytometry, respectively.ResultsPIGR levels were increased in the intima of early human atherosclerotic lesions and in patients with PAD, compared to controls.
Ldlr−/−/Pigr−/− mice showed elevated serum IgA and IgM levels, along with an increased number of germinal center B cells in both the spleen and PP.
Frontiers in Immunology published a clinical update in Infectious Disease on 23 Apr 2026.
The item focuses on Polymeric immunoglobulin receptor deficiency attenuates experimental atherosclerosis.
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