Medial Neovascularization: A Novel Mechanism of Aortic Dissection in a Hypertensive Population?

Journal of the American Heart Association, Volume 15, Issue 11 , June 2, 2026. BackgroundThis study aimed to elucidate the impact of vasa vasorum on the natural progression of aortic dissection in patients with hypertension.MethodsFull‐thickness ascending aortic walls from 43 participants (median age, 53 years; 32.6% women) were analyzed using pathological observation and shear stress measurement.

Comparisons among hypertensive dissection (AD, n=23), hypertensive control (n=12), and nonhypertensive dissection (non–HT‐AD, n=8) groups were performed using Kruskal–Wallis and repeated‐measures ANOVA tests.ResultsCompared with the control group, a higher density of vasa vasorum was observed within the outer third of the tunica media (medial neovascularization [MN]) in the AD group (adjustedP=0.02). In the AD group, MN frequently coincided with the site of medial tearing, and the MN grade was higher than in the other 2 groups (overall:P=0.01; non–HT‐AD versus AD group: adjustedP=0.05; control versus AD group: adjustedP=0.05).

Medial degeneration was observed in all of the groups. Compared with the non–HT‐AD group, the medial degeneration grade was even lower in the AD group (adjustedP=0.006).