The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large‐Artery Atherosclerotic Acute Ischemic Stroke

15 Jun 20264 min read0 viewsJournal Feed

GIST (Key Takeaways)

Journal of the American Heart Association, Volume 15, Issue 12 , June 16, 2026. Background. GNB3C825T polymorphism affects G protein–coupled receptor signaling, influencing platelet function, inflammation, and cardiovascular risk. This study aimed to investigate the unknown effects of theGNB3C825T polymorphism on recurrent stroke risk in large‐artery atherosclerosis and its potential interaction with antiplatelet therapy.
Methods. Using the CNSR‐III (Third China National Stroke Registry) data, we analyzed 1233 patients with large‐artery atherosclerotic acute ischemic stroke enrolled within 72 hours of onset. Whole‐genome sequencing was performed to identify theGNB3C825T polymorphism. Cox regression analysis was used to assess its association with 1‐year recurrent ischemic stroke after adjusting for vascular risk factors.
Associations with antiplatelet regimens and mediating effects of inflammatory biomarkers in the overall cohort were also evaluated. Results. Carriers of theGNB3825T‐allele (CT/TT, 72.7%) exhibited a significantly lower risk of 1‐year recurrent ischemic stroke than noncarriers (adjusted hazard ratio, 0.67 [95% CI, 0.48–0.93];P=0.02). In exploratory analyses, the association was observed in the aspirin monotherapy subgroup, but the interaction with aspirin use was not significant.
Elevated baseline interleukin‐6 partially attenuated this genetic protection in the overall cohort (mediation proportion, –9.82%;P=0.02).Conclusions. TheGNB3825T‐allele was associated with a reduced risk of recurrent stroke in patients with large‐artery atherosclerotic acute ischemic stroke. In exploratory analyses, this association was observed in the aspirin monotherapy subgroup; however, the formal interaction with aspirin use was not statistically significant. These findings support a potential prognostic role of theGNB3C825T polymorphism and warrant further validation in independent cohorts.

Clinical Editorial

Journal of the American Heart Association published a clinical update in Cardiology on 15 Jun 2026. The item focuses on The GNB3 C825T Polymorphism Is Associated With Decreased Risk of Recurrence of Large‐Artery Atherosclerotic Acute Ischemic Stroke. Open the detail page to review the full original feed content.