Impact of Coronary Artery Disease Extent on GRACE Risk Score Prognostic Performance After STEMI

10 Mar 20264 min read0 viewsJournal Feed

GIST (Key Takeaways)

Journal of the American Heart Association, Volume 15, Issue 6 , March 17, 2026. Background. The GRACE (Global Registry of Acute Coronary Events) score is well validated for risk stratification in non–ST‐segment–elevation myocardial infarction, but less well established in ST‐segment–elevation myocardial infarction (STEMI), particularly relative to coronary disease burden.
We therefore assessed its prognostic performance in a STEMI cohort, accounting for baseline coronary disease extent. Methods. We studied 1099 patients with STEMI from the CardioLines Coronary Biobank (2015–2021) with evaluable GRACE score and follow‐up data.
Patients were stratified by the number of coronary vessels with significant stenosis. The primary end point was all‐cause death at 1 year; the secondary end point was a combined end point, including all‐cause death, recurrent acute coronary syndrome, stroke, and revascularization at 1 year. Results.
Mean GRACE scores increased with the number of diseased vessels (P<0.001). In multivariable models, each 10‐point increase in GRACE score was associated with a 31% higher risk of all‐cause death and a 14% higher risk of the combined end point at 1 year.

Clinical Editorial

Journal of the American Heart Association published a clinical update in Cardiology on 10 Mar 2026.

The item focuses on Impact of Coronary Artery Disease Extent on GRACE Risk Score Prognostic Performance After ST‐Segment–Elevation Myocardial Infarction.

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