Journal of the American Heart Association, Volume 15, Issue 12 , June 16, 2026. BackgroundIschemic stroke (IS) imposes a substantial global burden, yet the metabolic pathways linking proinflammatory dietary patterns to its pathogenesis remain unclear.MethodsWe conducted a 3‐phase prospective analysis within 502 410 participants from the UK Biobank.
A total of 249 metabolites determined with high‐throughput nuclear magnetic resonance spectroscopy and 168 directly metabolites were included. In phase I, sex‐specific metabolic signatures were selected based on Energy‐Adjusted Dietary Inflammatory Index (E‐DII) with least absolute shrinkage and selection operator.
In phase II and III, a Cox proportional hazards regression model was used to evaluate the associations of E‐DII and selected metabolic signatures with IS risk. The joint effect of E‐DII and polygenic risk score were also evaluated.ResultsThe metabolic signature, comprising 32 metabolites in women and 45 metabolites in men, were determined based on E‐DII, with correlation coefficients of 0.279 and 0.296 (P<0.001).
Journal of the American Heart Association published a clinical update in Cardiology on 09 Jun 2026.
The item focuses on Proinflammatory Diet, Plasma Metabolome, and the Risk of Ischemic Stroke: Evidence From the UK Biobank.
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