Motor neuron disease in Africa: a critical appraisal of the literature

Motor neuron disease (MND) refers to a group of neurodegenerative diseases that cause motor neuron degeneration and death. The most common subtype, amyotrophic lateral sclerosis (ALS), is characterized by both upper and lower motor neuron impairment, which can manifest clinically in the bulbar region or asymmetrically in a limb.

Typically, the disease progresses over several months, and death from respiratory failure occurs within 2–5 years of onset. As we highlight in this Review, data on MND in Africa are sparse, although common observations in this region — and in other populations with relatively low life expectancy — include apparent earlier disease onset and lower disease incidence compared with the rest of the world.

In view of the HIV epidemic in Africa, we critically examine the evidence for an association between ALS and HIV infection. We briefly discuss conditions that might be regarded as ALS mimics and summarize the limited data on MND genetics in this region.