This record is the PubMed/NCBI entry for a randomized controlled trial titled “Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock.” The citation lists publication in the New England Journal of Medicine (NEJM) with DOI 10.1056/NEJMoa2601969 and an Epub date of 2026 Apr 24. The PubMed page includes navigation and links to the full-text resources maintained by NCBI.
The entry enumerates a large multi-institutional group of investigators led by Fran Balamuth and Scott L. Weiss and including many coauthors from pediatric emergency medicine, pediatric critical care, anesthesiology, and research institutes across the United States, Canada, Australia, New Zealand, and Costa Rica. Affiliations include major children’s hospitals, university departments of pediatrics, and pediatric sepsis programs, indicating a multinational and multidisciplinary collaboration.
The PubMed record identifies the article as a Randomized Controlled Trial in NEJM (volume and page numbers provided in the citation). The DOI (10.1056/NEJMoa2601969) is given, and links to full text on the NEJM site and a free PMC copy are included on the PubMed page. This entry therefore functions as a bibliographic pointer to the complete manuscript and supporting materials.
The title and PubMed classification indicate that this is a randomized controlled trial directly comparing two fluid strategies—balanced fluid versus 0.9% saline—in the management of pediatric septic shock. The research question implied by the title is whether choice of crystalloid (balanced solution compared with normal saline) affects clinically meaningful outcomes in children treated for septic shock.
The excerpt available in the JINA source includes:
These elements establish provenance, access, and the high-level trial topic.
The PubMed excerpt supplied here does not include the article abstract, methods, results, numerical data, outcomes, statistical analyses, or authors’ conclusions. Specifically, the following trial details are not present in the provided source text and therefore cannot be restated or summarized here:
Because these critical data elements are not present in the provided PubMed excerpt, they are not available to report here and must be obtained from the full-text article.
From the bibliographic information alone, this publication represents an important, high-profile randomized trial addressing a common clinical decision in pediatric resuscitation: selection of crystalloid fluid in septic shock. The NEJM venue and the multinational author group suggest the study could influence practice and guidelines if it reports definitive outcome differences. However, without the abstract, methods, or results in the provided source text, no conclusions about efficacy, safety, or recommendations can be drawn here.
Clinicians and researchers interested in the trial’s findings should consult the full NEJM article or the PubMed Central copy to review trial design, statistical approach, outcomes, and subgroup or safety analyses before changing clinical practice.
The PubMed entry includes direct links to the NEJM full-text page and a free PMC article. Use the DOI (10.1056/NEJMoa2601969) or PubMed identifier (PMID as shown on the PubMed page) to retrieve the complete manuscript. When reviewing the full article, pay attention to: enrollment criteria, primary and secondary endpoints, absolute and relative treatment effects, adverse events, subgroup analyses, and authors’ stated limitations. Those sections will provide the necessary evidence to interpret clinical relevance and applicability.
Note: This rewritten summary is limited to the content present in the supplied PubMed/NCBI excerpt. Detailed trial methods, results, and the authors’ conclusions were not included in the provided source text and therefore are not reported above. For complete and actionable information, consult the full NEJM article or the PubMed Central copy linked from the PubMed record.