by Emily Hemendinger, John A. Thompson, Jennifer Fishman, Katie Sinsko, Hannah Gebhardt, Rachel A.
Davis Purpose Obsessive-Compulsive Disorder (OCD) severely impairs quality of life (QoL) in many sufferers. Deep Brain Stimulation (DBS) can be effective therapy for OCD that is refractory to standard treatment options, which include medications and cognitive behavioral therapy/exposure and response prevention therapy.
The purpose of this study was to acquire qualitative data about the impact of DBS on QoL for people who have treatment refractory OCD. Methods Ten subjects who received DBS surgery and are receiving ongoing DBS programming participated in this study.
Pre- and post-surgery assessments (Q-LES-Q-SF and Y-BOCS) were analyzed for 8 of the 10 participants, and narratives from all 10 subjects were coded for themes. To assess individual correlations, analyses were completed within each participant, using solely their data points.
Results In six out of 8 subjects, improved QoL scores correlated with a decrease in Y-BOCS score, although this was only found to be significant in 2 of the 6 subjects.
PLOS ONE (Medicine) published a clinical update in Research Highlights on 29 May 2026.
The item focuses on Beyond the Numbers: Quantitative and qualitative analysis of quality of life after deep brain stimulation for OCD.
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