by Chengshu Liang, Kai Wang Background Endothelial dysfunction is critical in the pathogenesis of acute kidney injury (AKI). It sought to investigate the role of endothelial activation and stress index (EASIX) in risk stratification and treatment optimization for critically ill patients with AKI.
Methods Utilizing MIMIC-Ⅳ 3.1 database, a retrospective cohort study was undertaken. Given the non-normal distribution, EASIX was transformed logarithmically.
The endpoints were 1-year and ICU all-cause mortality. The association was assessed using Kaplan-Meier curves, Cox models, restricted cubic splines and propensity score via overlap weights.
Subgroup analyses were conducted to assess optimal population for EASIX application and to preliminarily explore its potential role in guiding treatment strategy optimization. Results It comprised 17624 patients with AKI, exhibiting 1-year and ICU mortality rates of 44.6% and 19.2%.
Elevated log2(EASIX) levels were independently associated with an increased 1-year mortality (HR: 1.41, 95% CI: 1.32–1.50) and ICU mortality (RR: 1.49, 95% CI: 1.38–1.62), as a finding corroborated by overlap-weighted propensity score analysis.
PLOS ONE (Medicine) published a clinical update in Research Highlights on 06 May 2026.
The item focuses on Endothelial activation and stress index in risk stratification and treatment optimization for critically ill patients with acute kidney injury: A retrospective cohort study from MIMIC-Ⅳ database.
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