Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. SignificanceThe role of DIRAS2 in epilepsy remains unexplored.
In this study, we demonstrate that DIRAS2 alleviates epileptic seizure susceptibility and activity and regulates the excitatory/inhibitory balance. Mechanistically, DIRAS2 suppresses ...
PNAS published a clinical update in Research Highlights on 25 Mar 2026.
The item focuses on DIRAS2 modulates MAPK pathway–mediated ferroptosis to regulate excitation/inhibition balance and seizure susceptibility.
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