Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. SignificanceCasitas B-lineage lymphoma (CBL) E3 ubiquitin ligases mediate ubiquitin conjugation of epidermal growth factor receptor (EGFR) but their functional contributions to EGFR endocytic trafficking and signaling remain poorly defined. Here, we ...
PNAS published a clinical update in Research Highlights on 27 Mar 2026.
The item focuses on Small-molecule CBLB inhibitor abolishes EGFR ubiquitination, reduces receptor endocytosis, and diminishes cell motility signaling.
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