STAT+: FDA eyes expanding testosterone therapy for libido

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Psychedelics and testosterone are front and center today, but also we note that GLP-1’s dominance in obesity may not be as inevitable as it looks. Early animal data from GLP-1 pioneers suggest that pathways like GIP-glucagon offer effectiveness and better overall tolerability.  The need-to-know this morning Kailera Therapeutics raised $625 million in an initial public offering — the largest-ever Wall Street debut for a drug company.

Kailera is developing obesity drugs licensed from China.  Do we even need GLP-1 anymore?  The scientists whose work helped spur the development of GLP-1-based obesity drugs are now questioning whether that target is necessary at all. Instead, they’re proposing that using GIP-glucagon as a dual target could deliver comparable — or even superior — weight loss, without the nausea and dosing limitations that come with current therapies.

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