Skin Conditions Linked With Type 2 Diabetes In Northern Finland Cohort

10 Jul 20264 min read1 viewsJournal Feed

GIST (Key Takeaways)

Objectives There is evidence to suggest that alterations in skin health often co-occur with type 2 diabetes (T2D). However, the underlying mechanisms remain unclear. Despite their clinical relevance, skin conditions are often underdiagnosed in diabetes care.
This study applied variable selection methods to identify key dermatological factors linked to T2D and examined their direct and indirect associations. Design Prospective birth cohort study. Participants This study analysed data from the Northern Finland Birth Cohort 1966, including 1906 participants (1024 women, 882 men) at ages 31 and 46 years.
At age 46 years, the cohort participants, living in the region of Northern Finland, were invited to a general health clinical examination including the assessment of their T2D status and a dermatological examination. Methods Prior to performing a path analysis, we developed a data-driven procedure to select 47 possible skin-related variables for the model. The variable selection combined test-based methods (ie, a univariate analysis and a backward, forward and stepwise logistic regression) and penalty-based/machine learning methods (ie, Least Absolute Shrinkage and Selection Operator, Ridge, minimax convex penalty and Sparse Stepwise Regression).