Bone physiological adaptations to whole-body vibration in mouse models: A Systematic Review

14 Jul 20264 min read0 viewsJournal Feed

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by Roberto Bonanni, Ida Cariati, Lucio Caprioli, Cristian Romagnoli, Angela Falvino, Saeid Edriss, Pierangelo Cifelli, Giovanna D’Arcangelo, Elvira Padua, Virginia Tancredi, Giuseppe Annino Whole-body vibration (WBV) is known to mechanically stimulate bone tissue, modulating its turnover and microarchitecture. Our systematic review aimed to collect the available evidence on the effects of WBV in mouse models, comparing the different experimental protocols and results obtained.
A systematic literature search was conducted in the MEDLINE, Scopus, and Web of Science databases, in accordance with PRISMA guidelines. Experimental studies investigating the effects of WBV on healthy mice of different age groups, models of osteoporosis or fracture healing, and other models of bone loss were included.
Methodological quality was assessed using SYRCLE’s RoB tool to analyze the reliability of the results and the risk of bias and the adapted GRADE approach to determine the overall level of certainty of the evidence. Twenty-nine studies were included, of which 10 were on healthy mice, 9 on osteoporotic or fracture healing models, and 10 on other models of bone loss.

PLOS ONE (Medicine) published a clinical update in Research Highlights on 14 Jul 2026.

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PLOS ONE (Medicine)