Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
We conducted a cross-sectional serosurvey for Oropouche virus (OROV) among residents of Amazonas State, Brazil, during 2015–2016. We detected OROV neutralizing antibodies in 85/814 (10.4%) participants; seroprevalence was higher in Manaus (49/440 [11.1%]) than in Coari (36/374 [9.6%]).
Those findings suggest OROV circulation in Amazonas State before 2015. Oropouche virus (OROV) is a neglected and reemerging vectorborne orthobunyavirus endemic in Central and South America since the 1950s ( 1 , 2 ).
OROV is mainly transmitted to humans by the bite of infected midges ( Culicoides paraensis ), which also spread OROV among sloths and other animals in the sylvatic cycle ( 3 ). OROV infection in humans causes Oropouche fever, characterized by self-limiting febrile illnesses but that can, in rare cases, lead to hemorrhagic, neurologic, and maternal–fetal complications, even death ( 1 , 4 ).
CDC Emerging Infectious Diseases Journal published a clinical update in Infectious Disease on 10 Apr 2026.
The item focuses on Seroepidemiologic Study of Oropouche Virus, Amazonas State, Brazil, 2015–2016.
Review the original article for the full source wording and details.