Circulation, Volume 153, Issue 13 , Page 948-962, March 31, 2026. BACKGROUND:With pulmonary hypertension (PH), a pulmonary artery wedge pressure (PAWP)>15 mm Hg is used to diagnose left heart dysfunction, but some patients with adjudicated group 1 PH demonstrate PAWP>15 mm Hg.
The primary objective of the study was to evaluate group 1 PH with high PAWP>15 mm Hg.METHODS:Patients with adjudicated group 1 PH from PVDOMICS between 2016 and 2019 were separated into high PAWP(>15 mm Hg) or normal PAWP and compared with adjudicated combined pre- and postcapillary (Cpc) PH related to heart failure with preserved ejection fraction (HFpEF). Participants underwent dynamic right heart catheterization and metabolomics.
Findings were validated in 3 independent cohorts with adjudicated group 1 PH (validation cohorts 1 and 2 with exercise right heart catheterization and validation cohort 3 with resting right heart catheterization).RESULTS:Of 325 patients with group 1 PH (73% women, mean age 53.0±14.3 years), 15% (n=48) had high PAWP.
Circulation published a clinical update in Cardiology on 13 Feb 2026.
The item focuses on Elevated Pulmonary Artery Wedge Pressure in Group 1 Pulmonary Hypertension.
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