This PubMed entry documents an article titled "Intratumoral Mycobacterium abscessus promotes cytidine deaminase mutagenesis in non-small cell lung cancer," published in Signal Transduct Target Ther on 2026 Sep 1 (11[1]:355). Identifiers listed in the record include DOI 10.1038/s41392-026-02878-z and PubMed ID 42675040.
The PubMed page excerpt provided supplies bibliographic metadata (journal, date, volume/issue/page, DOI, PMID) but does not include the article abstract or experimental data in the excerpt used as the source for this rewrite.
The publication lists multiple authors with several designated as having contributed equally: Xun Li, Mei-Ting Li, Ke-Peng Ou, and Pan-Qi Gao are noted as equal contributors. Additional authors named in the record include An-Hua Xiao, Ji Yang, Jia-Ning Li, Wan-Yan Deng, Meng-Jun Bie, Ai-Long Huang, Xiao-Feng Shi, and Quan-Xin Long.
Affiliations shown in the PubMed record are primarily based in Chongqing, China, and include:
Contact emails for some authors are included in the affiliation list on the PubMed page (as metadata).
The article title highlights three central concepts that define the reported focus:
These terms appear as the primary keywords and represent the biological agent, the mutagenic mechanism, and the clinical disease setting, respectively.
The PubMed record includes the following verifiable items:
The page header also reiterates that this is an official NCBI/NLM PubMed record and displays navigation and account elements from the PubMed website; those site interface elements are not part of the scientific content but are present in the captured source text.
The PubMed excerpt used as the source for this rewrite does not provide the abstract content or experimental details. Specifically, the following critical elements were not reported in the available source text and therefore cannot be restated or summarized here:
Because these items are absent from the provided PubMed excerpt, any attempt to supply them would require accessing the full article text. The source prohibits inventing or inferring unreported results or numbers.
The title suggests a research focus at the intersection of infection and oncogenesis: intratumoral colonization by Mycobacterium abscessus and an association with cytidine deaminase mutagenesis in non-small cell lung cancer. From the title alone one can infer that the authors investigated a possible link between a bacterial species found within tumors and mutational processes driven by cytidine deaminases, which are enzymes known to deaminate cytosine and can contribute to mutational signatures in cancer genomes.
However, the PubMed excerpt does not provide supporting data, nor does it indicate whether the reported relationship is observational, mechanistic, correlative, or causal. Clinical or therapeutic implications—such as whether this finding would affect treatment selection, prognosis, or infection management in lung cancer patients—are not available in the source text and should not be assumed.
To evaluate the study methods, results, and clinical relevance, consult the full text via the DOI link (10.1038/s41392-026-02878-z) or access Signal Transduct Target Ther directly. The PubMed entry includes sufficient bibliographic identifiers (journal, DOI, PMID) to locate the complete publication. For clinicians and researchers seeking to interpret or apply the findings, read the full article to review the experimental design, cohort details (if clinical), mutation analyses, statistical robustness, and authors' discussion of implications and limitations.
If you would like, I can attempt to retrieve and summarize the article abstract and key results if you provide access to the full text or allow me to fetch the abstract from PubMed. Based on the current source excerpt alone, no additional factual clinical details beyond the metadata can be provided.