Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of malignant lymphoma in adults. Although 60–70% of patients achieve remission with first-line immunochemotherapy (R-CHOP or pola-R-CHP), approximately 30%-40% of patients still experience develop refractory or relapsed disease.
Treatment resistance still remains as the major challenge in DLBCL patient management. Although there is no significant synergy among the components in the R-CHOP or Pola-R-CHP regimens, cross-resistance between these treatments is minimal.
Elucidating the mechanisms underlying drug resistance and developing innovative therapeutic strategies are essential for enhancing the clinical outcomes for this patient cohort. This article provides a detailed and up-to-date review of the molecular mechanisms of resistance to the current treatment options in DLBCL.
We lastly highlight potential strategies for the rational management of treatment resistance.
This review synthesizes current knowledge on mechanisms driving resistance to first-line immunochemotherapy in diffuse large B‑cell lymphoma (DLBCL) and outlines potential approaches to manage refractory or relapsed disease.
It focuses on molecular determinants relevant to R‑CHOP and pola‑R‑CHP regimens.
Narrative review of published molecular and translational findings; specific methods, selection criteria, and evidence grading were not reported in the source.
Adults with DLBCL receiving first‑line immunochemotherapy; the source notes that 60–70% achieve remission while roughly 30–40% develop refractory or relapsed disease.