ObjectiveTo evaluate the association of serum uric acid (SUA) with established lupus nephritis (LN) and to explore its prospective association with incident LN in systemic lupus erythematosus (SLE) patients presenting with preserved renal function.MethodsWe enrolled 97 SLE patients with preserved renal function (creatinine clearance ≥ 90 mL/min), including 58 with baseline LN and 39 without LN (NLN). Baseline associations were evaluated using multivariable logistic regression, with a sensitivity model further adjusting for baseline glucocorticoid dose, mycophenolate mofetil use, and cyclophosphamide use.
Model discrimination was compared by Area Under the Curve (AUC) and DeLong testing. The baseline NLN cohort was followed for 3 years, and incident LN was analyzed using a Cox model adjusted for baseline Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).ResultsBaseline SUA was higher in LN than in NLN patients (489.2 ± 80.8 vs.
339.8 ± 104.2 µmol/L, p < 0.001).
Frontiers in Immunology published a clinical update in Infectious Disease on 07 May 2026.
The item focuses on Serum uric acid in systemic lupus erythematosus with preserved renal function: a cross-sectional and longitudinal analysis.
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