Keeping weight off might not require full-dose GLP-1 drugs, trials suggest

Incretins are gut hormones that help regulate appetite, blood sugar, and digestion. Medications that mimic these hormones include GLP-1–based treatments , such as Zepbound , Wegovy , and Foundayo , which can lead to significant weight loss.

However, weight regain after stopping these medications is common, with research showing that many people regain at least some weight after stopping therapy, especially without ongoing lifestyle support. Long-term weight maintenance represents one of the biggest challenges in obesity treatment.

Many people may require ongoing treatment to maintain results. Instead of stopping medication suddenly, some people may transition gradually to lower doses.

Alternatively, others may consider switching to oral formulations to improve adherence and maintain weight loss.