Nature Immunology, Published online: 30 March 2026; doi:10.1038/s41590-026-02476-9 A study shows that the unique pMHC repertoire of cortical thymic epithelial cells is crucial for the differentiation of cytotoxic CD8+ T cells, providing the TCR signaling disruption needed as thymocytes move into the medulla, where a different pMHC set is encountered.
Nature Immunology published a clinical update in Infectious Disease on 30 Mar 2026.
The item focuses on Solving the puzzle of CD8 T cell positive selection.
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